• br Material and methods br

  2018-10-29

  

  Material and methods Results Discussion Differentiated chondrocytes are capable of proliferating and secreting numerous growth factors and cytokines to form the extracellular matrix in mature cartilage (Fischer et al., 2010; Keller et al., 2011). During chondrogenesis, these events are prec

• Of the population that does respond to the peptides with

  2018-10-29

  

  Of the population that does respond to the peptides with changes in chronotropy ET-1, acting via ETA receptors, elicited a PKC-dependent, pertussis toxin- and 2-APB-insensitive positive chronotropic response. This finding is broadly consistent with a previous study in mESC-CMs (Kapur and Banach, 200

• As METH impairs self renewal capacity we also explored the

  2018-10-26

  

  As METH impairs self-renewal capacity, we also explored the influence of METH in DG stem cell-fate division, a suitable method to characterize the phenotype of cells that are derived from the division of one DG stem cell. Indeed, a stem cell can undergo symmetric cell division towards self-renewal,

• purchase A recently developed gene editing technology using

  2018-10-26

  

  A recently developed gene-editing technology using RNA-guided endonuclease (Gaj et al., 2013), which allows the desired gene to be inserted into a genomic safe harbor (GSH) area (Papapetrou et al., 2011), should be considered to avoid undesirable random genomic insertion of EOS-C(3+)-KR in the gener

• br Results br Discussion Insertion of reporter cassettes int

  2018-10-26

  

  Results Discussion Insertion of reporter cassettes into the Lgr5 locus has enabled characterization of mouse ISCs (Barker et al., 2007, 2010) and development of ex vivo organoid culture systems (Sato et al., 2009). Subsequent transplantation assays using fetal or adult ISCs have paved the way

• Human pluripotent stem cells hPSCs including

  2018-10-26

  

  Human pluripotent stem over here (hPSCs), including human embryonic stem cells (Thomson et al., 1998) and induced pluripotent stem cells (iPSCs) (Takahashi et al., 2007), provide an ideal in vitro model to recapitulate human hematopoietic development. We have shown that hPSC-derived HSC-like cells p

• We previously identified a role for

  2018-10-26

  

  We previously identified a role for the transcription factor Gata3 in prostate cancer (Nguyen et al., 2013). GATA3 expression is lost during cancer progression in both mouse and human prostates. In Pten-deficient mice, acute inactivation of Gata3 accelerates prostate cancer progression, while its su

• lysophosphatidic acid The electrical properties of cells wer

  2018-10-26

  

  The electrical properties of lysophosphatidic acid were recently analyzed by EIS during the differentiation of stem cells (Angstmann et al., 2011; Bagnaninchi and Drummond, 2011; Venkatanarayanan et al., 2013). These pioneering works have demonstrated a possibility of using changes in impedance as

• Study of microglia has been largely restricted to non

  2018-10-26

  

  Study of microglia has been largely restricted to non-human models (mostly mouse), since availability of fresh primary human microglia is very limited and they cannot be propagated. Moreover, microglia rapidly lose their unique identity when removed from the inos inhibitor environment and cultured

• their mathematical expectations follow the expressions br

  2018-10-26

  

  their mathematical expectations follow the expressions According to the CLT for independent random variables , for N → ∞  the expression tends to a standardized Gaussian random variable. Therefore for N ≫ 1 we have the following approximate equalities: where θ0, , are the standardized Gaussian

• br Introduction Light emitting diodes

  2018-10-26

  

  Introduction Light emitting diodes (LEDs) due to their technical and economic advantages (low power consumption, a long service life and low service costs, a small size, the absence of hazardous IR and UV radiation, ease of disposal) are the leading contenders for future light sources. Currently,

• br Explaining health inequalities Three main theories have b

  2018-10-26

  

  Explaining health inequalities Three main theories have been documented to account for health inequalities: materialist, psychosocial, and behavioural/cultural (Bartley, 2008). Methods The ‘Local Health Inequalities in an Age of Austerity: The Stockton-on-Tees Study’ is a mixed method, interd

• br Conflicts of interest br Acknowledgements

  2018-10-26

  

  Conflicts of interest Acknowledgements The authors are grateful for the fieldwork data collection undertaken by student and assistants from the Faculties of Environmental Design (Karina Lamy), Medicine (Lindsay Burton, Ann Toohey, Monica Viapiana), Science (Stefano Liccioli and Sarah Gingerick

• Greater access to fast food chains translates

  2018-10-26

  

  Greater access to fast food chains translates into an environment with increased opportunities to purchase and consume such items (Brug, 2008; Thornton, Bentley & Kavanagh, 2009). As governments at the Federal, state, and local levels strive to find new ways to improve enba health outcomes, a growi

• Additional models were tested to assess

  2018-10-26

  

  Additional models were tested to assess the robustness of the main results to the different specifications. These included whether having a history of bankruptcy prior to the age 40-health module influenced the overall results. None of the 370 women with a pre-40 health bankruptcy who were added, ho

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