• Several questions remain to be addressed The hormones and me

  2021-02-04

  

  Several questions remain to be addressed. The hormones and metabolites that modulate expression of EERγ in the steps leading to maturation need to be identified to learn more about physiological and pathophysiological regulation of EERγ in β cells. Considering that ERRγ repressed cell cycle genes in

• In summary EP signaling modulates heteromeric kainate recept

  2021-02-04

  

  In summary, EP1 signaling modulates heteromeric kainate receptors at multiple steps, both sensitizing mice to kainate-evoked status epilepticus and, separately, exacerbating the downstream consequences of status epilepticus. These results, together with those of Serrano et al. (2011) and Jiang et al

• br Materials and methods br

  2021-02-04

  

  Materials and methods Results Discussion Here we show expression of the EP1 receptor in the hippocampus of mice and the functional influence of the EP1 receptor on kainic wdr5 induced seizures. Mice lacking a functional EP1 receptor gene displayed a lower tendency to enter status epileptic

• br Materials and methods br Results Overexpression of KLF

  2021-02-04

  

  Materials and methods Results Overexpression of KLF2 increased the cell viability and reduced the LDH leakage rate and O2•− and ONOO− generation in H/R HUVEC model. To evaluate the effect of KLF2 on H/R HUVEC injury, KLF2 was overexpressed in HUVECs. Cell viability and extracellular LDH level

• br Conclusions br Declaration of interest br

  2021-02-04

  

  Conclusions Declaration of interest Acknowledgements Introduction Uncorrected obesity has been a major health problem and the prevalence of obesity is fast rising reaching an epidemic proportion [[1], [2], [3]]. Ample of clinical and experimental evidence has suggested that obesity leads

• The discovery of proteases that are active

  2021-02-04

  

  The discovery of proteases that are active in organic solvent media has greatly extended their ability in the synthesis of useful products. Microbial proteases which are able be catalyse in non-aqueous solvents present new expectation in enzyme applications. This kind of enzymes gives a major contri

• br Conclusion The present work

  2021-02-03

  

  Conclusion The present work describes the synthesis of 18 naphthoquinonolyl-1,2,3-triazole compounds based on natural product modification with antiplasmodial activity. Lapachol derivatives disclosed higher activity than the natural product. Six of these final modified lapachol 1,2,3-triazole com

• br Materials and Methods br Results br Discussion HSCs

  2021-02-03

  

  Materials and Methods Results Discussion HSCs have been identified as major collagen-producing Y-27632 in the injured liver (1), and activation of HSCs has become the central link for liver fibrosis (2). The factors that regulate the biological behavior of HSCs include soluble regulatory f

• ARA metabolites which are produced through cytochrome P

  2021-02-03

  

  ARA metabolites, which are produced through cytochrome P450 (CYP450) enzymes influence cardiovascular homeostasis. Human CYP4A11 and CYP1A2 metabolize ARA to 20-hydroxyecostearonic Zoledronic Acid (20-HETE) [11], which is a vasoconstrictor [12], platelet activator [13] and naturetic in the kidney [

• The aim of this study was to

  2021-02-03

  

  The aim of this study was to use molecular methods to characterise C. difficile isolates circulating in the Czech Republic from 2013 to 2015. Material and methods Discussion During a three-year period (2013–2015) a total of 32 hospitals voluntarily participated in this project, but only 11 ho

• Finally we have determined for the first

  2021-02-03

  

  Finally, we have determined for the first time that aromatase enzyme activity is necessary to observe IGF-1-dependent Darunavir Ethanolate receptor activation. Neuroestrogen synthesis has been shown to be important for the maintenance of synaptic spine density in hippocampal slice cultures (Kretz e

• br Benefits and risks of traditional

  2021-02-03

  

  Benefits and risks of traditional combined oestrogen–progestogen HRT regimens Combined oestrogen–progestogen regimens were developed to reproduce the short- and long-term benefits of oestrogen replacement therapy (ERT) and to simultaneously provide appropriate protection against oestrogen-related

• Estrogen receptor related receptor ERR like other members

  2021-02-03

  

  Estrogen receptor-related receptor γ (ERRγ), like other members of the ERR subfamily, is a constitutively active orphan nuclear receptor, though unlike ERRα and β, it is more selectively expressed in metabolically active and highly vascularized tissues such as heart, kidney, brain, and skeletal musc

• br Results br Discussion We

  2021-02-03

  

  Results Discussion We first tested for any adverse effect of ATR on learning and memory with a MWM test, which is used to assess hippocampal spatial learning and memory abilities in rodents (Vorhees and Williams, 2006). In the place navigation test, the escape latency – or time spent locating

• Altogether these data suggested that

  2021-02-02

  

  Altogether these data suggested that GlmU might be involved in the M. smegmatis biofilm mediated defence mechanisms. GlmU belongs to a metabolic pathway leading to UDP-GlcNAc from fructose-1-phosphate involved in the biosynthesis of peptidoglycan and lipopolysaccharide (Fig. 8). Recently, we demonst

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