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Protein ubiquitination occurs at the lysine residues and is
2020-05-16
Protein ubiquitination occurs at the lysine residues, and is mediated by the sequential reactions of ubiquitin-activating enzyme (E1), conjugating enzyme (E2), and ligase (E3). The first step in this process comprises the ATP-dependent activation of ubiquitin by E1 to form a ubiquitin–E1 conjugate.
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A major open question in the field of lipid mediators
2020-05-16
A major open question in the field of lipid mediators is the molecular nature of the PLA2 enzyme involved in the release of DHA and related omega-3 fatty acids from phospholipids as a first committed step for the generation of SPMs. Although by analogy with AA it is often assumed that cPLA2α may ser
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Because sex steroids and growth hormone play an
2020-05-16
Because sex steroids and growth hormone play an important role in the development and maintenance of hepatic CYP450 enzyme expression and ER expression, it is possible that exposure to endocrine active agents during gestation and perinatally could alter expression of these proteins. Therefore, these
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The Kaempferia parviflora extract met
2020-05-16
The Kaempferia parviflora extract met the criteria for a non-competitive interaction with CYP1A1 based on the decrease of Vmax and unchanged Km. The high Ki value and low IC50, as well as the high Km value was indicative of the weakness of the interaction between the Kaempferia parviflora extract an
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br Author Contributions br Acknowledgments
2020-05-16
Author Contributions Acknowledgments Introduction Osteoporosis is a common bone disease that frequently leads to disruption of the alveolar and systemic bones with age. Novel osteoanabolic strategies to treat osteoporotic bone loss or augment fracture repair efficiently are desired. Since b
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br Methods To study electrostatic substrate
2020-05-16
Methods To study electrostatic substrate channeling, we employed two methodologies, Brownian dynamics and a continuum model based on the Smoluchowski theory. Whereas Brownian dynamics simulations are useful for tracking the motion of individual particles, the continuum model is convenient for cal
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In order to gain further insights into the
2020-05-16
In order to gain further insights into the role of peptidases in B. xylophilus, four cysteine proteases highly secreted by B. xylophilus (Cardoso et al., 2016) were selected four further characterisation. Materials and methods Results and discussion Structural prediction and analysis The i
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The excitatory amino acid L glutamate
2020-05-16
The excitatory amino Asiaticoside sale L-glutamate or glutamate mediates most of the excitatory neurotransmission within the mammalian central nervous system (CNS) and has been implicated in numerous peripheral nervous system (PNS) pathways. The excitatory amino acids, including glutamate, are of gr
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The role of ARA cyp metabolites
2020-05-16
The role of ARA-cyp450 metabolites in the liver is still unclear [44]. However, ARA-cyp450 genes metabolize other fatty acids such lauric and palmitic L-Kynurenine [45]. It was found that decreased cyp4a expression caused fatty livers through reduction of fatty acid metabolism [46]. In this study,
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In general terms PLA s participate
2020-05-15
In general terms, PLA2s participate in the Lands cycle of phospholipid fatty A-1331852 recycling [1,15,25], whereby the fatty acid composition at the sn-2 position of phospholipids is tightly controlled by a balance between hydrolytic reactions mediated by PLA2s versus activation of the free fatty
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br Asb Proteins and Mitochondrial Function
2020-05-15
Asb Proteins and Mitochondrial Function Mitochondria are intracellular organelles in eukaryotic Myelin Basic Protein (87-99) and are the main sites of oxidative phosphorylation and ATP production. In addition, mitochondria serve as signal transduction docking stations in pyroptosis and regulate
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Since the interaction between the E and E is
2020-05-15
Since the interaction between the E2 and E3 is weak and transient, it has been difficult to identify novel interactions between specific E2/E3 complexes [59], [64]. Here we used a modified bait consisting of the Mulan RING domain fused to one of the four E2s isolated in our screen and expressed in y
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The murine subfamily members including and have been identif
2020-05-15
The murine subfamily members including , , , and have been identified and their encoded proteins showed deubiquitinating enzymatic activity , , , . It has been demonstrated that is an immediate-early gene induced by IL-3 in B-lymphocytes and is an IL-2 specific immediate-early gene in T-lymphoc
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Organometallic compounds exhibited remarkable potential for
2020-05-15
Organometallic compounds exhibited remarkable potential for the development of new cancer drugs not only due to the direct cytotoxicity but also to the drug targeting and active anticancer immune response ability [4]. Among the organometallic compounds, ferrocene is one of the most well-known compou
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The question remained as to why hCrm
2020-05-15
The question remained as to why hCrm1 was functional and mCrm1 was not in terms of Rev and HIV mRNA nuclear export, and previously we proposed three possibilities (Elinav et al., 2012). One was that human ido1 inhibitor had a positively acting factor that somehow stabilized the hCrm1 and Rev-RRE co
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