• Introduction Human cytomegalovirus CMV is a herpesvirus

  2020-07-29

  

  Introduction Human cytomegalovirus (CMV) is a herpesvirus which has a ubiquitous and worldwide distribution, and is the most frequent cause of congenital infection (Kenneson and Cannon, 2007). The prevalence is around 0.5–1% of all live births and is the leading cause of sensorineural hearing loss

• Due to the high attractiveness of E

  2020-07-28

  

  Due to the high attractiveness of E2 and E3 ligases as drug targets, a number of drug discovery assays have been published, based on detection by fluorescence (Dudgeon et al., 2010, Krist et al., 2016, Zhang et al., 2004), TAME synthesis (Davydov et al., 2004, Huang et al., 2005, Kenten et al., 200

• br Conclusions First it should be noted that even though

  2020-07-28

  

  Conclusions First, it should be noted that even though non-linagliptin DPP-4 inhibitor SPCs specified thresholds for dose adjustment in CrCl via the use of the Cockcroft-Gault formula at the time of the patients’ treatment, in January 2018, the sitagliptin SPC was changed to include glomerular Ma

• Introduction Mycobacterium leprae the causative agent of lep

  2020-07-28

  

  Introduction Mycobacterium leprae, the causative agent of leprosy, affects skin, peripheral nerves and upper respiratory tract [1]. Although leprosy has been eradicated from most of the countries, it still affects approximately a quarter of a million people from India [2]. Details of many bacteriol

• Materials and methods Restriction endonucleases T DNA polyme

  2020-07-28

  

  Materials and methods Restriction endonucleases, T4 DNA polymerase, Taq polymerase and a DNA ligation kit were purchased from Takara Shuzo, [α-32P]dCTP (3000 Ci/mmol) and a DNA sequencing kit were from Amersham, a Gene Clean II kit was from Bio 101, plasmid vector pET-3a was from Novagen, marker pr

• apexbio calculator DAPK is involved in the p

  2020-07-28

  

  DAPK-1 is involved in the p53 dependent apoptotic pathway and it is a mediator of γ-interferon induced apoptosis. DAPK-1 is also involved in other death signaling pathways (tumor necrosis factor-α, CD95 and transforming growth factor-β) and it blocks tumor metastasis in vivo. The loss of DAPK mRNA a

• In summary the present results provide evidence that

  2020-07-28

  

  In summary, the present results provide evidence that both CRF1 and CRF2 receptors within the BNST modulate the cardiovascular responses during emotional stress. Our data suggest that BSNT CRF1 receptor is involved in the mediation of the pressor and tachycardiac responses induced by restraint stres

• br Discussion The use of co

  2020-07-28

  

  Discussion The use of co-translational incorporation during fermentation [27] to introduce Hyp residues instead of Pro residues in a bacterial collagen has been demonstrated. Inclusion of NaCl in the medium further increases the level of Hyp incorporation. It has been proposed [27] that this is d

• In mouse lung arsenite enhances the

  2020-07-28

  

  In mouse lung, arsenite enhances the formation of cigarette smoke-induced 8-oxodeoxyguanine (Hays et al., 2006) and BaP-induced DNA adducts (Evans et al., 2004). Moreover, arsenite inhibits the repair of BaP-induced DNA adducts in human lung carcinoma A549 Pefloxacin sale (Schwerdtle et al., 2003),

• Xiaoji Decoction XJD has been used

  2020-07-27

  

  Xiaoji Decoction (XJD) has been used in the treatments of lung cancer for many years (Chai et al., 2014) and mechanistically has been shown to inhibit the growth of NSCLC Zinc protoporphyrin IX in vitro and in vivo (Chai et al., 2014). However, the mechanistic details of the potential therapeutic be

• br Methods br Results br Discussion Endothelial specific rei

  2020-07-27

  

  Methods Results Discussion Endothelial-specific reintroduction of eNOS in eNOS-KO resulted in a lower eNOS protein expression in different tissues of eNOS-Tg/KO. Therefore, we investigated vascular eNOS activity by acetylcholine-induced endothelium-dependent vasodilation in conductance and

• br Introduction Recruitment and activation of neutrophils

  2020-07-27

  

  Introduction Recruitment and activation of neutrophils (PMN) [1] are characterized by liberation of intracellular granules. Myeloperoxidase (MPO), stored in primary granules of PMN, is among the principal enzymes released. Of note, increased levels of circulating MPO can be also detected in patie

• br The invasion of extravillous trophoblast

  2020-07-27

  

  The invasion of extravillous trophoblast (EVT) into the decidualized endometrium is crucial in the determination of pregnancy outcome. Inadequate trophoblast invasion not only leads to implantation failure and spontaneous pregnancy loss but also results in the insufficient remodeling of spiral sub

• The synthesis of modified polymer

  2020-07-27

  

  The synthesis of modified polymer (PBI-adenine) is presented elsewhere [28] and the current study is focused on exploring the capability of this innovative material to remove a broad range of DNA alkylating agents from API organic solvent solutions, identify limitations for the use of PBI-adenine fo

• RDH belongs to C family of the

  2020-07-27

  

  RDH10 belongs to 16C family of the short-chain dehydrogenase/reductase (SDRs) superfamily of proteins [12], [13]. Notably, in human genome adjacent to the gene encoding RDH10 on chromosome 8 are located two other genes encoding members of the SDR16C family: retinol dehydrogenase epidermal 2 (RDHE2,

15806 records 789/1054 page Previous Next First page 上5页 786787788789790 下5页 Last page