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br Materials and methods br Results br Discussion CDK
2019-11-01
Materials and methods Results Discussion CDK4 has been identified recently as a potential therapeutic target in human breast cancer, liposarcoma, melanoma, and glioblastoma [[37], [38], [39]]. Due to the importance of CDK4 activity in cancer cells, CDK4 inhibitors have emerged as promising
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As previously stated the most unexpected finding from this
2019-11-01
As previously stated, the most unexpected finding from this series of compounds was the identification of a dimethyl isoxazole side chain that gave dramatically improved binding over the parent compounds. Holding this piece of the molecule constant, a series of analogs were made to further understan
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KX2-391 dihydrochloride synthesis The same reservoir of gene
2019-11-01
The same reservoir of KX2-391 dihydrochloride synthesis is involved in fusions in all types of cancers, which predominantly encode kinases and transcriptional factors [102]. This makes fusion genes potential pan-cancer targets, and renders tumor categorization based on genetic profiling therapeutic
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br Additional CDKs with a role
2019-11-01
Additional CDKs with a role in cancer Small molecule CDK inhibitors The majority of protein kinase inhibitors developed to date are type I inhibitors: they bind at the ATP–binding site, are ATP-competitive and target the kinase in its active state; with the activation loop DFG motif in the ‘in
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As suggested by previous data we identified that the
2019-11-01
As suggested by previous data [45], we identified that the N-terminal and C-terminal domains of DDX3 were enriched in intrinsically disordered regions (Fig. 6). We also found that this characteristic was conserved in the external domains of several homologs of DDX3 (from yeast to human) and all desc
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Mitophagy is a selective autophagic process
2019-11-01
Mitophagy is a selective autophagic process which leads to the degradation of damaged mitochondria in response to metabolic or environmental stress conditions. In this study, we found that LFS-01 treatment significantly enhances p62 in a time-dependent manner. We found that the upregulation of p62 i
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GSK 5959 receptor Characterization factor is another variabl
2019-11-01
Characterization factor is another variable suggested in the presented correlation. Specific gravity (SG) and normal boiling point of hydrocarbons are needed to calculate Watson characterization factor [61], [62]: The boiling point of bitumen cannot be precisely measured, because bitumens contain
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We showed for the first time that ivermectin
2019-11-01
We showed for the first time that ivermectin significantly reduced the pH-induced response of the pHCl-A variant at 300nM, whereas fipronil and γ-BHC had no significant effects on the channel unlike in RDL and GluCl (Fig. 4). Such a concentration is similar to the threshold at which ivermectin activ
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The N B method has the overall advantage that
2019-11-01
The N&B method has the overall advantage that it is not restricted to certain dyes specific for energy transfer [55], and is also able to detect higher order receptor Valinomycin on the focal point in living cells. Conclusion The N&B method has shown to be a powerful tool to locate and quantify
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br Acknowledgements br Introduction L Rhamnosidases EC
2019-11-01
Acknowledgements Introduction α-L-Rhamnosidases (EC 3.2.1.40) are glycosyl hydrolases (GHs) that cleave terminal α-l-rhamnose from a large number of natural products [1]. The action of α-L-rhamnosidases (α-RHAs) has been reported, among others, on different complex substrates such as heteropol
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BQ-123 We found that E and GEN each has
2019-10-31
We found that E2 and GEN each has mostly similar effects on recruitment of the epigenetic modulators to the MB-COMT distal promoter (summarized in Table 2). These effects are associated with increased promoter methylation and gene suppression of COMT. It is noted that the array of epigenetic modulat
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To understand the behavior of enzymes in ILs
2019-10-31
To understand the behavior of enzymes in ILs at a molecular level, it is first desirable to dissolve enzymes in the solvents. For soluble catalysts, there are many relatively simple spectroscopic and other techniques for obtaining accurate information at a molecular level. Parker et al. [9] reported
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Although CCR expression clearly identifies MBC precursors wi
2019-10-31
Although CCR6 expression clearly identifies MBC precursors within the GC, we found that the expression of this chemokine receptor by responding LDC1267 synthesis was not required for MBC differentiation and had no detectable impact on the GC subsets analyzed in this study. Although this is in agree
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L-817,818 EBI remains an orphan GPCR and the
2019-10-31
EBI2 remains an orphan GPCR and the identity and source of its ligand are yet to be described. Molecular studies of EBI2 have suggested that this receptor has constitutive activity, similar to that observed for many herpesvirus-encoded 7TM receptors (Benned-Jensen and Rosenkilde, 2008, Rosenkilde et
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The following is the supplementary
2019-10-31
The following is the supplementary data related to this article. Introduction Diacylglycerol kinase (DGK) phosphorylates diacylglycerol (DG) to produce phosphatidic CHIR-090 (PA) (Baldanzi, 2014, Goto et al., 2006, Merida et al., 2008, Sakane et al., 2007, Topham and Epand, 2009). To date, ten m
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