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CPG a metalloenzyme derived from sp was the elected
2019-10-25
CPG2, a metalloenzyme derived from sp., was the elected enzyme for the first pilot-scale clinical trial of ADEPT. This enzyme has no mammalian homologue and activates glutamic D-Luciferin sodium salt prodrug derivatives of several nitrogen mustards alkylating agents., , , , , A bond cleavable by
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c-Myc Peptide australia At present there have been relativel
2019-10-24
At present, there have been relatively few studies that evaluated potential correlations between pulmonary and pleura metastases, hilar and mediastinal c-Myc Peptide australia nodes, and organs associated with distant metastasis and EGFR mutations [33,34,37]. Further research on these relationships
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In conclusion as illustrated in Fig G
2019-10-24
In conclusion, as illustrated in Fig. 5G, in response to MNNG-induced DNA damage, PARP-1 appears to have dual roles in determining the cell fate in response to MNNG: PARP-1 activation is the cause of non-apoptotic cell death via ATP depletion and PARP-1 activation is able to elicit a self-protective
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br Introduction Diacylglycerol kinase DGK is a lipid metabol
2019-10-24
Introduction Diacylglycerol kinase (DGK) is a lipid-metabolizing enzyme that phosphorylates diacylglycerol (DG) to produce phosphatidic hmg coa reductase (PA) [[1], [2], [3], [4]]. DG and PA act as lipid second messengers in a wide variety of biological processes. Ten DGK isozymes (α, β, γ, δ, η
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Introduction Quassinoids are natural products formed through
2019-10-24
Introduction Quassinoids are natural products formed through the oxidative degradation of triterpene derivatives with anti-inflammatory, antimicrobial, antineoplastic, and antiplasmodial effects (Chakraborty and Pal, 2013; Houël et al., 2013). They are characteristic ingredients of the family Simar
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The mammalian two hybrid results
2019-10-24
The mammalian two-hybrid results described above were all obtained in 293T cells, and thus the higher RLU observed specific to the hCrm1 fusion could be consistent with human Calpain Inhibitor XII having an unknown activator that interacts with hCrm1 HEAT repeat 9A and somehow facilitates Crm1-Rev/
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By live imaging of GUL
2019-10-24
By live imaging of GUL-1-GFP, we observed the kinetics of aggregate movement within the cell. One of the marked characteristics of GUL-1-GFP cytosolic (but not nuclear-associated) aggregate motion was a “comet-like” movement that was found to be dependent on the presence of properly polymerized micr
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We consider the following perturbation of problem where is
2019-10-24
We consider the following perturbation of problem (2):where ∊>0 is an identity element. For a given ∊, we solve problem (3) to get the solution (x, y, λ). As ∊ decreases slowly toward 0, the optimum of F follows to the global optimum of F0. This set of constraint conditions is called the central pat
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In this report we established mouse models suitable for
2019-10-24
In this report, we established mouse models suitable for human retinal cell transplantation by introducing phosphodiesterase 6B (Pde6b) mutant allele from retinal degeneration (rd) mouse models into NOG background. Pde6b (rd1) and Pde6b (rd10) mice are well-studied and frequently used animal models
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It is well known that
2019-10-24
It is well known that acrolein, a metabolite of cyclophosphamide, is responsible for the cyclophosphamide-induced cystitis, and that acrolein is capable of activating TRPA1 channels expressed in the capsaicin-sensitive primary afferents [2], [11]. In this context, it is likely that the early phase o
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Apart from its high affinity the selection
2019-10-23
Apart from its high affinity, the selection of GW2580 as Iberin lead in our radiotracer development program was motivated by its exceptional selectivity. The observed profound impact of small structural modifications on the selected panel of four kinases tested prompted us to conduct comprehensive k
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Since its inception ADEPT approach has been widely reported
2019-10-23
Since its inception, ADEPT approach has been widely reported by many groups using a variety of enzymes and prodrugs (see reviews) [12], [14]. Both mammalian and non-mammalian enzymes have been utilised. Of the mammalian variety, human β-glucuronidase in combination with many prodrugs [17], [18] and
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HC-030031 mg br Conclusions CK inhibition protects young
2019-10-23
Conclusions CK2 inhibition protects young and aging WM function against an ischemic episode by preserving oligodendrocytes and axonal structure by maintaining mitochondrial integrity. CK2 recruits CDK5 and AKT/GSK3ß signaling to mediate WM ischemic injury in a differential spatiotemporal manner s
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p-nitro-Cyclic Pifithrin-α SPR was used to measure biomolecu
2019-10-23
SPR was used to measure biomolecular kinetic interactions between TERRA G-quadruplex and ligand in the present study. SPR is a widely used method, but cannot tell which specific type of interaction happened. Compounds with similar structures probably have similar mechanism of interaction, while comp
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br Materials and methods br Results br Discussion
2019-10-23
Materials and methods Results Discussion We have evaluated the breast cancer prevention potential of PR blockade under conditions that included exposure to progestogens that are relevant to women (progesterone and MPA) and are known to differ in their receptor-binding and down-stream effect
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