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MCL has a poor long term response to
2019-06-12
MCL has a poor long-term response to current treatment strategies, for the most commonly used R-CHOP chemotherapy (rituximab, cyclophosphamide, doxorubicin, vincristine, prednisolone), the remission rate is good (75–96%) but brief in duration. Despite the study of several other chemotherapy regimens
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Pharmacokinetics analysis of AT on SCID mice bear
2019-06-12
Pharmacokinetics analysis of AT-406 on SCID mice bearing MDA-MB-231 tumors has shown that AT-406 achieves a maximum concentration in plasma between 1.5μM and 9.9μM, and a maximum concentration in tumor tissue between 0.5μM and 18.2μM, depending on the dose and administration route (intravenous versu
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All patients with symptomatic cardiac AL amyloidosis had poo
2019-06-12
All 4 patients with symptomatic cardiac AL amyloidosis had poor prognoses. The median survival period for these 4 patients was 12.3 months (minimum=4 months, maximum=28 months) (Table 1). The patient in Case 2, whose BNP level was the highest of the 4 patients, had the shortest survival period. Howe
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Therefore it is necessary to identify the accuracy
2019-06-12
Therefore, it is necessary to identify the accuracy of ECG in predicting a spontaneous syncope. Some waterproof Holter ECGs are commercially available; however, their use is not yet widespread. Moreover, patients may not experience syncope symptoms during the recording period. Given that the ILR can
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Although these studies demonstrated the efficacy of pacemake
2019-06-12
Although these studies demonstrated the efficacy of pacemaker treatment for preventing or reducing VVS, all 3 trials were retrospective and uncontrolled [10]. Therefore, RCTs of cardiac pacing in VVS were proposed in the late 1990s. The era of RCTs: is pacemaker efficacy due to a placebo effect?
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In September a high level meeting of the UN called
2019-06-12
In September 2011, a high-level meeting of the UN called for a concerted global response to the growing challenge of non-communicable diseases (NCDs). Subsequently, in 2013, the World Health Assembly adopted a WHO-generated action plan and set a target of 25 × 25: a 25% reduction in premature mortal
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El reto que est por venir en Am
2019-06-12
El reto que está por venir en América Latina es que sus estados reconocidos como pluriétnicos no reciclen políticas indigenistas con el objeto de enmascarar su oposición PCI-32765 la diversidad cultural, ni tampoco revivan proyectos jerárquicos para atender las diversidades culturales. Es indispensa
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Su visi n sobre el
2019-06-12
Su visión sobre el tema parte de tres premisas: 1) aunque el régimen democrático es un componente indispensable de la democracia, es insuficiente para caracterizar ALW-II-41-27 manufacturer ésta adecuadamente. El Estado y, en algunos sentidos, el contexto social general también son componentes impor
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Seg n Alejandra Pita y Aimer Granados las
2019-06-12
Según Alejandra Pita y Aimer Granados, las revistas culturales han sido redescubiertas por los historiadores como fuente de enorme valor para el estudio de grupos y redes intelectuales, y en este aspecto se han constituido como objeto de estudio autónomo. Sin embargo, como hemos señalado anteriormen
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As condi es desta reinser o seriam consolidadas a partir
2019-06-12
As condições desta “reinserção” seriam consolidadas endothelin receptor antagonists partir do chamado “autogolpe”, quando Fujimori fechou o congresso e interveio no poder judicial em abril de 1992, decretando à moda argentina um “Gobierno de emergencia y reconstrucción nacional”. Em uma perversão da
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Precisamente en ese a o de llegar a a
2019-06-12
Precisamente, en ese año de 1569, llegaría dhfr inhibitor Perú el virrey Francisco de Toledo, quien iniciaría, en 1572, un proceso judicial frente a don Carlos y don Felipe Yupanqui por su supuesto involucramiento en la revuelta del Inca sublevado en Vilcabamba, Túpac Amaru. Una de las consecuencias
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BLU9931 manufacturer Introduction Radiofrequency catheter ab
2019-06-11
Introduction Radiofrequency catheter ablation (RFCA) has been established as an effective and safe non-pharmacological therapy for arrhythmias [1]. Idiopathic left ventricular outflow tract ventricular arrhythmias (LVOT-VAs) arising from the LVOT are rare compared with VAs arising from the right ve
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Introduction Cardiac resynchronization therapy CRT reduces
2019-06-11
Introduction Cardiac resynchronization therapy (CRT) reduces mortality and morbidity in selected heart failure patients with impaired left ventricular (LV) function and cardiac dyssynchrony [1]. Most patients receive CRT with a defibrillator (CRT-D) because the indications for an implantable cardio
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phospholipase c inhibitor Patients were divided randomly int
2019-06-11
Patients were divided randomly into two groups at the time of hCG administration. Patients in Group 1 (n = 38; 33.6%) underwent IUI 24 hours after hCG administration. Group 2 (n = 75; 66.4%) underwent IUI 36 hours after hCG administration. All patients were instructed to have intercourse when the do
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Since BM impairs the balance between bone formation and
2019-06-11
Since BM impairs the balance between bone formation and bone resorption, altered bone remodeling activities can be assessed directly by measuring the components of affected bone cells or indirectly by analyzing metabolic products released from the bone matrix by changed rates of bone formation or re
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