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Neurotrophic factors regulate RGC survival and
2018-11-09
Neurotrophic factors regulate RGC survival and neurite growth through both common and distinct downstream signaling pathways (Goldberg et al., 2002). For example, MAPK/ERK and PI3K/AKT signaling pathways are involved in BDNF induced neuronal survival and axonal growth (Nakazawa et al., 2002) whereas
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mi2 Considerable work has gone into evaluating the impact of
2018-11-09
Considerable work has gone into evaluating the impact of putative adjuvants on innate immune activation and on adaptive immune responses to model mi2 and potential vaccines (Longhi et al., 2009; Kastenmuller et al., 2012; Trumpfheller et al., 2008; Stahl-Hennig et al., 2009; Perret et al., 2013; Ca
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br Experimental Procedures br Acknowledgments This
2018-11-08
Experimental Procedures Acknowledgments This work was supported by funding from auda ICR. F.B.A. was supported by the Erasmus Work Placement Programme. We thank Drs. Taiping Chen (MD Anderson Cancer Center) for providing J1 WT and Dnmt1-null ESCs and Masaki Okano (Riken) for providing TKO ESCs
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kainic acid Our previous study Ara et al demonstrated the pr
2018-11-08
Our previous study (Ara et al., 2011) demonstrated the protective efficacy of hypoxic-preconditioning against hypoxic–ischemic injury in newborn piglet model. We showed that hypoxic exposure for 3h, 24h before hypoxia–ischemia, was effective in reducing kainic acid damage in newborn piglets while i
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We recently found that E
2018-11-08
We recently found that E-cad function cannot be replaced by N-cad during the formation of the trophectoderm, the first polarized epithelium formed during mammalian development. In the blastocyst, the E-cad extracellular domain provides a unique and indispensable survival signal by facilitating Igf1r
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Our observations are consistent with previous findings
2018-11-08
Our observations are consistent with previous findings in vivo that Ahr expression is silenced at the 2-cell stage, becoming again detectable in late blastocysts (Peters and Wiley, 1995; Dey and Nebert, 1998; Wu et al., 2002) and in most developing organs during post-implantation development (Abbott
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The following are the supplementary data related to
2018-11-08
The following are the supplementary data related to this article. Acknowledgments This work was supported by Marie-Curie IEF FellowshipPIEF-GA-2009-254644 (J.F.) and the Netherlands Institute for Regenerative Medicine (NIRM) (E.W., M. vd. B. and T.N.). Introduction Human ES (hES) cells are p
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br Materials and methods br
2018-11-08
Materials and methods Results Discussion Here we establish a molecular signature for unmodified SCDSs that were initiated by individual multipotent SSCs in comparison with SCDSs that were initiated by Zalcitabine that were not multipotent, based upon their differentiation capacity as deter
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Cell adhesion molecules CAMs are transmembrane proteins that
2018-11-08
Cell adhesion molecules (CAMs) are transmembrane proteins that are responsible for mediating adhesion of cells to other cells and/or the extracellular matrix via their extracellular domains, while their intracellular domain interacts with the cytoskeleton. Thus, CAMs provide a direct link between th
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br Methods br Results br Discussion
2018-11-08
Methods Results Discussion The structural and functional immaturity of the differentiated cardiomyocytes are major obstacles for developing hPSC-VCM-based cell replacement therapies (Kong et al., 2010; van den Heuvel et al., 2014). Although a number of studies showed that the overall matura
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K03861 Our findings showing an increase of growth factors ex
2018-11-08
Our findings showing an increase of growth factors expression in miR133-CPCs upon stress conditioning and the amelioration of cardiac functions after miR133-CPCs transplantation post-AMI are in agreement with a recent publication that demonstrates that previous supplementation (“priming”) of SCA1+/C
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br Heteroplasmy mitochondrial segregation and disease In
2018-11-08
Heteroplasmy, mitochondrial segregation and disease In an individual with a mitochondrial disease, different cells or populations may have differing amounts of the mutant mitochondria, ranging from complete homoplasmy – individuals with all mutant mitochondrial DNA as occurs in Leigh\'s Syndrome
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An important step towards further ACC CSC characterization i
2018-11-08
An important step towards further ACC-CSC characterization is identification of CD markers which, in combination with CD133, may be used for FACS sorting and multiplexed CyTOF analysis of ACC-heterogeneity and their signaling states. Such studies may significantly advance understanding of ACC-CSC ro
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Most remarkably we identified Nppb Bnp a well
2018-11-08
Most remarkably, we identified Nppb (Bnp), a well-studied marker in cardiovascular disease, as a novel putative Shox2 target gene. This gene was analyzed as working myocard marker and turned out to be significantly upregulated in Shox2 SAN-like serine threonine protein kinase and in right atrial ti
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br Results br Discussion Here we report on different mutant
2018-11-08
Results Discussion Here we report on 14 different mutant hESC lines, termed DM1 hESCs, that were derived from DM1-affected preimplantation embryos. Previous studies employed DM1 hESCs to explore the causal role of CTG expansion on neurite formation and neuromuscular connections and for charact
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