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HTT forms a complex with
2018-11-06
HTT forms a complex with dynein and dynactin in neurons to promote axonal microtubule-based vesicular transport (Caviston et al., 2007; Gauthier et al., 2004). Here, we demonstrate that HTT regulates spindle orientation through its interaction with dynein. Dynein and dynactin are recruited to the ce
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br Results br Discussion We demonstrated a
2018-11-05
Results Discussion We demonstrated a significant positive correlation between the susceptibility of hiPSC-CMs to Mox-induced FPD prolongation and QT prolongation in healthy individuals within a certain concentration range. Thus, in vitro assays using hiPSCs derived from healthy individuals may
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The extracellular matrix ECM is a network of secreted protei
2018-11-05
The extracellular matrix (ECM) is a network of secreted proteins that function in concert to structurally support purchase Nocodazole and regulate cellular processes (Rozario and DeSimone, 2010). The ECM is an important component of the BM hematopoietic microenvironment, where it can sequester cytok
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br Competing interests br Acknowledgements This work
2018-11-05
Competing interests Acknowledgements This work was supported by JSPS KAKENHI Grants, numbers 24320169, 26245060, and 15H02964. The data for this secondary analysis, “Japanese General Social Surveys, the JGSS Research Center at Osaka University of Commerce,” was provided by the Social Science J
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Table compares age specific mortality
2018-11-05
Table 2 compares age-specific mortality rates between whites and African-Americans, aggregated over the four time periods. Consistent with the literature, African-American mortality rates exceed those of whites in all age groups except for 75 years or higher. The gap between whites and African-Ameri
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Extending this multinational evidence linking
2018-11-05
Extending this multinational evidence linking parental divorce and children’s health disadvantage, we ask whether this association is uniform or if it glycoprotein inhibitors varies across the subcontinent—specifically, according to the commonality of divorce. Studies of Europe have found that the
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International comparisons are also valuable for studies eval
2018-11-05
International comparisons are also valuable for studies evaluating the population-level number of deaths attributable to a behavioral risk factor because these studies often rely on estimates of death risks from the behavioral factor under investigation (Preston & Stokes, 2011; Rostron, 2011). In su
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br Materials and methods br Results and
2018-11-05
Materials and methods Results and discussion Concluding remarks The compositions and properties of three subtropical soils sampled from respective active disposal sites around the City of Johannesburg (CoJ) were studied together with the chemical alterations that occurred when percolated wi
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br Calibration and correction methods of
2018-11-05
Calibration and correction methods of trp channels contents Calibration and correction methods of the isotopic ratios After the true signal intensity of the measured isotopes is obtained by interference correction, the mass fractionation of isotopic ratios should be corrected by rigorous corr
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Boron B is a quintessentially crustal element Marschall and
2018-11-05
Boron (B) is a quintessentially crustal adenosine receptor agonist (Marschall and Jiang, 2011). Its average abundance in the mantle is relatively low, whereas rocks of the continental crust show relatively high average abundances, containing a large fraction of Earth\'s B budget (Dutrow and Henry,
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Downstream applications may include additional
2018-11-05
Downstream applications may include additional algorithms for causality assessments following successful case ascertainment. This may help the clinician for example, to discriminate whether a specific adverse event was triggered by ‘natural’ infection, chenodeoxycholic acid or drug administration, a
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Given that A cells we
2018-11-05
Given that A549 Autophagy Compound Library we used are not derived from the small airways but are a transformed cell line with a pneumocyte phenotype, and our BMPR2 protein and mRNA expression work was performed in PBMCs but not lung tissue, we performed eQTL look-up in lung cell types (including w
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The present study quantifies the level of reassurance
2018-11-05
The present study quantifies the level of reassurance a parent may have on diagnostic testing that their child does not have NF1 if there is no sequence variant in NF1 or SPRED1 when their child has 6 or more CAL. Around 25% of children tested did not have an identifiable mutation. Using a Bayesian
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Stunting affects approximately million children
2018-11-05
Stunting affects approximately 165 million children under five, many of whom live in Africa (36.5%) (Black et al., 2013) where stunting rates in many areas are over 40% (Global Data Lab, 2016). Besides being associated with an increased mortality, stunting has negative long-term effects on cognitive
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Several conflicting large scale population based studies
2018-11-05
Several conflicting large-scale population-based studies published recently (e.g. (Lau et al., 2015; Moriya et al., 2015; Tsunoda et al., 2014)) indicated that buy tropisetron moderate (or ‘non-alcoholic’) alcohol consumption either has a beneficial or detrimental association with prevalence or dev
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