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    • Spearman s rank correlation was performed to detect the

    2018-11-12

    Spearman\'s rank correlation was performed to detect the correlation between our measurements and clinical staging for all patients (n = 33).
    Results The efficacy of exposure correction was validated through comparison of photos prior to and after processing (Figure 3). Exposure correction resulted in a 16.97% ( BWcorrected − BWoriginal /BWcorrected) difference in BW.‏ The average BW was 54.98 mm in all patients, 25.79 mm in type I-2 patients, 37.41 mm in I-3, 54.08 mm in I-4, 72.10 mm in II-1, and 85.53 mm in II-2 (Table 1). The values of BW were correlated with Savin scale stages clinically (rBW = 0.967), which was significant statistically (p < 0.05). Figure 4 demonstrates the balding area (green contour) and ellipse (red contour) for FPHL patients at different Savin scale stages.
    Discussion FPHL is a common disease in females with hair loss. Clinical staging for FPHL using the Ludwig and Savin scales is based on visual inspection, which may cause much variation in disease assessment and treatment among physicians. For this reason, we proposed a CAIS to measure BW to help physicians in clinical staging of FPHL. Prior to measurement, exposure correction was performed by Hermite spline. This is the first attempt to be applied in clinical use, which can correct the possible artifacts in biased photos. Exposure correction and its compensation for biased photos under different photographic conditions can be very useful for more precise evaluation, to achieve better consistency and reproducibility. This was validated through comparison of photos prior to and after processing. In this study, exposure correction resulted in a 16.97% difference in BW.‏ Table 1 demonstrates the correlation between Savin scale grading and values of BW. The values of BW were correlated with Savin scales clinically (rBW = 0.967). The values between different Savin scales were significant statistically (p < 0.05). From results of our study, quantitation of BW may be used to evaluate balding status and monitor the progression of hair loss in patients with FPHL. The reason for measuring BW is that it actin polymerization inhibitor was easy be apply in clinical use. Physicians may just measure the width of the central balding area for objective evaluation of patients with FPHL and to monitor progression of hair loss and treatment response by repeated measurement in their offices. This may be further assisted by more data collected from future studies on the range of BW in each scales of Savin or Ludwig. In conclusion, BW measured by a CAIS was useful for clinical assessment of patients with FPHL and even for quantitative follicular unit transplantation surgery. The results from the present study are encouraging for future research.
    Introduction Several skin disorders can affect quality of life (QoL). Skin disease results in strong negative emotions, annoying symptoms, and the lack of social and occupational abilities. The skin not only provides thermal and physical protection, but also represents our physical appearance; defective skin often results in low self-esteem. The effects of different skin diseases on patients vary and are not always directly proportional to the severity of the disease. The extent to which skin diseases affect the QoL of patients depends on many factors such as the nature of the disease, the duration of the disease, and the site of involvement. Over the past decade, issues related to the QoL of patients with skin diseases are gradually being taken more seriously, and scholars have tried to use various methods to evaluate QoL. Psoriasis is not a rare skin disease, with a prevalence of approximately 1–2% in Caucasians and a lower prevalence in Mongolians. Its pathogenesis and progression are not only related to genetic reason, but also emotional stress, drugs, infections, and physical trauma. In addition, conditions such as inflammatory bowel disease and arthritis are related complications of psoriasis. Therefore, this disease may result in poor appearance and impair daily life functions. Furthermore, it cannot be completely cured, which often leads to psychological distress in patients. Emotional stress may also lead to the deterioration of clinical symptoms in patients with psoriasis. Therefore, a vicious cycle is formed, which not only increases stress in patients, but also negatively affects the relationship of trust between patients and physicians. Currently, the QoL of patients with psoriasis in Taiwan is not well studied. This aims of this study are to understand the degree of influence of emotional factors on the QoL of patients with psoriasis in Taiwan and to enable dermatologists provide better comprehensive medical care to patients.