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Different responses in feed intake have been noticed
2022-02-15
Different responses in feed intake have been noticed following administration of exogenous GHRL (peripherally or centrally) depending on animal species. In mammals, injection of GHRL stimulates food intake (orexigenic effect) (reviewed in Kaiya et al., 2013b). In contrast, in domestic birds, exogeno
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br Role of ghrelin in reward and addiction In addition
2022-02-15
Role of ghrelin in reward and addiction In addition to its well-known effects on 2-Deoxycytidine homeostasis regulation at the hypothalamic level [reviews in (Al Massadi et al., 2017, Muller et al., 2015)], ghrelin also has the ability to increase food motivation acting on hypothalamic and extra-
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Some previous findings indicate that GALP has an influence
2022-02-15
Some previous findings indicate that GALP has an influence on AVP and OT secretion from the posterior pituitary gland. Cunningham et al. (2004) noted that the expression of GALP mRNA was increased in the neurohypophysis of lactating rats compared to non-lactating rats, whereas GALP mRNA expression i
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VS strategies have been building momentum
2022-02-15
VS strategies have been building momentum in G4 drug discovery both as a low-cost enrichment step and as a lead development step in the discovery pipeline, which our laboratory has previously discussed [31]. Whereas traditional HTS methods rely on obtaining and screening hundreds or thousands of com
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FPR activation stimulates multiple signal transduction pathw
2022-02-15
FPR1 activation stimulates multiple signal transduction pathways responsible for various neutrophil functions, such as adhesion, chemotaxis, phagocytosis, toxins of secretory granules, and superoxide anion radical (O2) production, which contribute to the physiological inflammatory response associate
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Studies have revealed that ferroptosis is non apoptotic
2022-02-15
Studies have revealed that ferroptosis is non-apoptotic and peroxidation-driven form of cell death that requires abundant and accessible cellular Fe2+, and thus, the balance of Fe2+ metabolism is of great significance in regulating the process of ferroptosis (Cao and Dixon, 2016; Xie et al., 2016; Y
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carbenoxolone In the same research group released a
2022-02-15
In 2017, the same research group released a free internet accessible database (HemeOxDB, http://www.researchdsf.unict.it/hemeoxdb), to make it easier the analysis of the literature and, consequently, the design of potent and selective HO-1 inhibitors. The database reported the entire set of HO-1 and
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br Conclusion B esterases and reproductive parameters can be
2022-02-15
Conclusion B-esterases and reproductive parameters can be used as effect biomarkers of the aquatic contamination with chlorpyrifos. In P. corneus exposed for 14 days to the insecticide, the carboxylesterases determined with p-NFB proved to be the most sensitive biomarker. However, exposure to env
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Considering that loss of LAG expression results in increased
2022-02-14
Considering that loss of LAG-3 k145 results in increased CD4+ T cell homeostatic expansion, and that the ability of a cell to proliferate is tightly coupled to its metabolic profile, we hypothesized that LAG-3 regulates naive CD4+ T cell metabolism. Our results indicate that, indeed, Lag3-deficient
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In this study with the use of
2022-02-14
In this study, with the use of 13C515N2-labeled glutamine, we observed that 13C515N2-labeled glutamine produces a wide range of NAAG isotopologues and its precursors: NAA and glutamate. The NAAG production from glutamine is consistently more elevated in MYC-ON lymphoma and OVCAR4 compared to MYC-OFF
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br Material and methods br Results br
2022-02-14
Material and methods Results Discussion Accumulating evidence suggests that the hippocampus is sensitive to noise-induced hearing loss and other forms of sensory deprivation, which deprives the hippocampus of sensory information required for its normal operations such as spatial navigation
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br Results br Discussion Using a novel
2022-02-14
Results Discussion Using a novel viral vector for norepinephrine-targeted gene deletion, we have shown that glucocorticoid receptor cell adhesion molecules from locus coeruleus norepinephrine neurons reduces social interaction specifically in female mice. This effect is not attributable to ch
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Inflammatory pain is very common in the clinic A
2022-02-14
Inflammatory pain is very common in the clinic. A study demonstrated that galanin was upregulated after nerve injury or inflammation (Ma and Bisby, 1997). It has been reported that galanin plays an important role in the transmission of nociceptive information in the spinal cord of rats with inflamm
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br Conclusions br Introduction Bioinformatics analysis shows
2022-02-14
Conclusions Introduction Bioinformatics analysis shows that there are about 300,000 G-rich sequences in human genome if searching with the consensus sequence (G3+N1-7G3+N1-7G3+N1-7G3+) [1], and their localizations are non-random. These G-rich sequences always localize in functional regions, su
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Based on this evidence future research should be directed
2022-02-14
Based on this evidence, future research should be directed towards the identification of actual receptor oligomeric states at the analyzed cellular surfaces. The macromolecular organization of these oligomeric receptors might establish informational hubs, which relay ligand/receptor interactions in
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