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Purification of Rv c In
2024-10-29
Purification of Rv2477c. In order to investigate the catalytic capabilities of Rv2477c, we expressed the protein as an N-terminal histidine-tagged fusion protein in E. coli BL21 cells and purified the protein by cobalt-affinity chromatography. As shown in Fig. 2A, the 65 kDa fusion protein was expre
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Lower LDL C mediated by variants in
2024-10-29
Lower LDL-C mediated by variants in the ACL gene is causally associated with the risk of cardiovascular events. Because, genetic variants that mimic the effect of an ACL inhibitor have the same effect on the risk of cardiovascular events per unit change in LDL-C as variants that mimic the effect of
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A strain previously reported as demonstrating strong antifun
2024-10-29
A strain previously reported as demonstrating strong antifungal activity and suitability for food applications is Lactobacillus reuteri R29 (Axel et al., 2016, Oliveira et al., 2015). Oliveira et al. (2015) demonstrated that the cell-free supernatant (cfs) of medium fermented for 48 h with this stra
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Analysis of the crystal structures of LAPs from
2024-10-29
Analysis of the crystal structures of LAPs from E. coli[29], bovine eye lens [30], Pseudomonas putida[27], tomato [31] and P. falciparum[32] revealed that the monomer of M17-family LAP is composed of two domains: the smaller, variable N-terminal domain and the larger, conserved C-terminal domain tha
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br Aldehyde sensors to monitor substrate levels
2024-10-28
Aldehyde sensors to monitor substrate levels Previous efforts to ameliorate metabolic diseases frequently relied on biochemical methods which could measure the levels of toxic substrates in melatonin receptor agonist or bodily fluids (blood and serum or plasma, urine, cerebrospinal fluid). Thera
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br Materials and method br Result and discussion br
2024-10-28
Materials and method Result and discussion Conclusion Acknowledgments This work is partly supported by the University Research Committee (URC) of the Senate of The Federal University of Technology, Akure. The authors thanked IFS for the funds (F/4449 1F and F/4449-2F) used to purchase th
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br Hypoadiponectinemia in metabolic syndrome APN belongs str
2024-10-28
Hypoadiponectinemia in metabolic syndrome APN belongs structurally to the complement 1q family and is found at high concentrations (>0.01% of total protein) in the serum of healthy individuals [6]. Given the abundance of APN in plasma, it is assumed that alterations in plasma levels of APN might
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AACOCF3 Drug resistance development often involves structura
2024-10-28
Drug resistance development often involves structurally un-related drugs and, specifically both conventional and targeted agents. IGROV-1/Pt1 AACOCF3 are characterized by resistance to cisplatin and reduced sensitivity to inhibitors of EGF-R and MEK, the up-stream activator of ERK1/2, associated wit
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br Funding br Ethics br
2024-10-28
Funding Ethics Conflict of interest Acknowledgements Introduction Hepatic fibrosis occurs in response to different etiologies of chronic liver injury, which is mainly accompanied by pathological benzydamine synthesis of excessive extracellular matrix (ECM) of the liver, as the common
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In bacteria H gler et al Kanao et al a
2024-10-28
In bacteria (Hügler et al., 2007, Kanao et al., 2001), a glaucophyte alga (Ma et al., 2001), green algae/land plants (Fatland et al., 2002), and filamentous fungi (Nowrousian et al., 2000), ACL enzyme activity requires ACLA, and ACLB (referred to here as dual-subunit ACL, or dsACL) (Kanao et al., 20
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With wide spread use of corticosteroids to combat inflammati
2024-10-26
With wide-spread use of corticosteroids to combat inflammation and allergies, even children are susceptible to corticosteroid-induced muscle wasting. Although non-steroidal SGRMs that spare muscle and bone, but have significant anti-inflammatory effects, have been preclinically developed and tested,
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br Applications of ATN in clinical trials In pivotal trials
2024-10-26
Applications of ATN in clinical trials In pivotal trials, the use of biomarkers will also have to be considered in the context of regulatory risk and scrutiny. Although an important intended application of the framework is in research studies, its use will undoubtedly impact clinical development
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br Conclusion br Acknowledgement This work was supported by
2024-10-26
Conclusion Acknowledgement This work was supported by JSPS KAKENHI (Grant Number 15K18770). Introduction Neural crest STF 31 synthesis are multipotent progenitors in the vertebrate embryo that give rise to a vast array of different cell types including pigment cells, craniofacial skeleton
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Interaction between AhR and ligands leads
2024-10-26
Interaction between AhR and ligands leads to AhR transformation (Fig. 1), characterized by a rapid receptor nuclear translocation and the formation of AhR/Arnt complex and the release of the chaperone proteins. Following AhR transformation, the AhR/Arnt complex binds to its cognate DNA consensus seq
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The excellent potencies selectivities and improved PK associ
2024-10-26
The excellent potencies, selectivities and improved PK associated with the piperazine class triggered more extensive off-target screenings of the highlighted compounds. A screen of more than 100 enzymes, receptors, and ion channels resulted in activity at the norepinephrine transporter (NET). This m
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