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Cysteine protease inhibitors representing several chemical s
2020-01-13
Cysteine protease inhibitors representing several chemical scaffold types are effective in halting parasite replication without toxicity to the host (Renslo and McKerrow, 2006). A vinyl sulfone cysteine protease inhibitor, K11777, is completing final Good Laboratory Practice (GLP) preclinical tests
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In conclusion our work led to the
2020-01-13
In conclusion, our work led to the characterization of some signalling events of the CysLT1 receptor variants, at several levels, and showed that a punctual serine mutation could alter the response of receptors to cysLTs. Although atopy is a complex phenotype implicating different cell types, mediat
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We consider the following perturbation of problem where is a
2020-01-13
We consider the following perturbation of problem (2):where ∊>0 is an identity element. For a given ∊, we solve problem (3) to get the solution (x, y, λ). As ∊ decreases slowly toward 0, the optimum of F follows to the global optimum of F0. This set of constraint conditions is called the central pat
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br Materials and methods br Results br Discussion
2020-01-13
Materials and methods Results Discussion This study demonstrates that various progestogens combined with E2 had different effects on breast cell growth. These effects had an inverse correlation with the changes of the PRA/PRB ratio. E2\'s antiapoptotic effects on MCF-7 Quinacrine hydrochlor
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corticotropin releasing factor The acid base properties of t
2020-01-13
3. The acid-base properties of the IL are important issues to consider because protonation changes caused by Brønsted-acidic or basic ions may result in enzyme deactivation [29]. Thereby, the acid-base properties of the newly designed IL need proper control for enzymes by selection of appropriate ca
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In terms of its protease
2020-01-13
In terms of its protease activity, MME has a broad range of substrates being able to target glucagon, bradykinin, GLP1, and several other urokinase of circulating small molecules [25]. MME has been shown to target free insulin B-chain [32], although whether MME could target and degrade the insulin
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The enantiomeric ratio ER of chiral compounds accumulated
2020-01-13
The enantiomeric ratio (ER) of chiral compounds accumulated in organisms has been found to be different among species (Borga and Bidleman, 2005, Harner et al., 1999, Warner et al., 2005, Wiberg et al., 2000), indicating enantioselective accumulation of chiral compounds are species-specific. The ER o
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Ketorolac br EBI structure and expression
2020-01-13
EBI2 structure and expression The gene encoding EBI2 was originally identified together with EBI1 (CCR7) as the most highly upregulated gene in Epstein–Barr virus-infected Burkitt\'s lymphoma cells [18]. EBI2 belongs to the rhodopsin-like subfamily of seven transmembrane GPCRs [19]. Although it i
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Contrary to the downregulation of S PR family
2020-01-13
Contrary to the downregulation of S1PR family GPCRs, CLL cells have increased mRNA expression of the lysophosphatidic tachykinin receptor (LPA) family receptors LPAR1, LPAR3 and LPAR4 compared to normal B cells [47]. Increased LPAR1 mRNA has been shown to be associated with more aggressive disease [
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br Significance Our understanding of
2020-01-13
Significance Our understanding of the ubiquitin biology has been rapidly expanding. The role of the ubiquitin system in the pathogenesis of numerous disease states has increased the interest in finding new strategies to pharmacologically interfere with the enzymes responsible of the ubiquitinatio
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br E Ubiquitin Ligases Regulate
2020-01-13
E3 Ubiquitin Ligases Regulate Central and Peripheral T Cell Tolerance During the random process of somatic recombination, T cell receptors (TCRs; see Glossary) that recognize self-antigens are commonly generated. Notably, meticulously precise filtering mechanisms, termed tolerance, are necessary
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In the present study we
2020-01-13
In the present study, we implemented the dendritic RCA-induced formation of amplifying DNAzyme catalytic labels strategy for sensitive and accurate assay of MTase activity and the detection of DNA methylation. In comparison with the traditional RCA process, the proposed strategy achieved high amplif
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Because conventional KO mice die
2020-01-13
Because conventional KO mice die within 24h of birth, it is difficult to analyze higher U-104 functions using them. Therefore, in this study, we generated brain-specific conditional DGKδ-KO mice and used these mice to perform behavioral and pharmacological tests. Results Discussion OCD is a
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In this study we examined a possible association between
2020-01-13
In this study, we examined a possible association between the 19-bp A922500 and the 9-bp repeat in the DHFR gene and the risk of spina bifida in 121 mothers of a spina bifida affected child, 292 control women, 109 spina bifida patients and 234 pediatric controls using a case-control design. Furtherm
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The study reported here had the primary
2020-01-13
The study reported here had the primary goal to compare the methylation of HPV late genes with methylation of the DAPK promoter, and with histological or cytological diagnoses among high-risk patients that were referred to a colposcopy clinic based on abnormal cervical cytology. Based on the literat
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