• We recently found that E

  2018-11-08

  

  We recently found that E-cad function cannot be replaced by N-cad during the formation of the trophectoderm, the first polarized epithelium formed during mammalian development. In the blastocyst, the E-cad extracellular domain provides a unique and indispensable survival signal by facilitating Igf1r

• Our observations are consistent with previous findings

  2018-11-08

  

  Our observations are consistent with previous findings in vivo that Ahr expression is silenced at the 2-cell stage, becoming again detectable in late blastocysts (Peters and Wiley, 1995; Dey and Nebert, 1998; Wu et al., 2002) and in most developing organs during post-implantation development (Abbott

• The following are the supplementary data related to

  2018-11-08

  

  The following are the supplementary data related to this article. Acknowledgments This work was supported by Marie-Curie IEF FellowshipPIEF-GA-2009-254644 (J.F.) and the Netherlands Institute for Regenerative Medicine (NIRM) (E.W., M. vd. B. and T.N.). Introduction Human ES (hES) cells are p

• br Materials and methods br

  2018-11-08

  

  Materials and methods Results Discussion Here we establish a molecular signature for unmodified SCDSs that were initiated by individual multipotent SSCs in comparison with SCDSs that were initiated by Zalcitabine that were not multipotent, based upon their differentiation capacity as deter

• Cell adhesion molecules CAMs are transmembrane proteins that

  2018-11-08

  

  Cell adhesion molecules (CAMs) are transmembrane proteins that are responsible for mediating adhesion of cells to other cells and/or the extracellular matrix via their extracellular domains, while their intracellular domain interacts with the cytoskeleton. Thus, CAMs provide a direct link between th

• br Methods br Results br Discussion

  2018-11-08

  

  Methods Results Discussion The structural and functional immaturity of the differentiated cardiomyocytes are major obstacles for developing hPSC-VCM-based cell replacement therapies (Kong et al., 2010; van den Heuvel et al., 2014). Although a number of studies showed that the overall matura

• K03861 Our findings showing an increase of growth factors ex

  2018-11-08

  

  Our findings showing an increase of growth factors expression in miR133-CPCs upon stress conditioning and the amelioration of cardiac functions after miR133-CPCs transplantation post-AMI are in agreement with a recent publication that demonstrates that previous supplementation (“priming”) of SCA1+/C

• br Heteroplasmy mitochondrial segregation and disease In

  2018-11-08

  

  Heteroplasmy, mitochondrial segregation and disease In an individual with a mitochondrial disease, different cells or populations may have differing amounts of the mutant mitochondria, ranging from complete homoplasmy – individuals with all mutant mitochondrial DNA as occurs in Leigh\'s Syndrome

• An important step towards further ACC CSC characterization i

  2018-11-08

  

  An important step towards further ACC-CSC characterization is identification of CD markers which, in combination with CD133, may be used for FACS sorting and multiplexed CyTOF analysis of ACC-heterogeneity and their signaling states. Such studies may significantly advance understanding of ACC-CSC ro

• Most remarkably we identified Nppb Bnp a well

  2018-11-08

  

  Most remarkably, we identified Nppb (Bnp), a well-studied marker in cardiovascular disease, as a novel putative Shox2 target gene. This gene was analyzed as working myocard marker and turned out to be significantly upregulated in Shox2 SAN-like serine threonine protein kinase and in right atrial ti

• br Results br Discussion Here we report on different mutant

  2018-11-08

  

  Results Discussion Here we report on 14 different mutant hESC lines, termed DM1 hESCs, that were derived from DM1-affected preimplantation embryos. Previous studies employed DM1 hESCs to explore the causal role of CTG expansion on neurite formation and neuromuscular connections and for charact

• mct2 inhibitor The contribution of LRRK to

  2018-11-08

  

  The contribution of LRRK2 to PD pathology has yet to be fully elucidated. LRRK2 has been proposed to act upstream of SNCA and tau to promote aggregation, but it may also act independently to promote neuron loss in the absence of aggregate pathology (Taymans and Cookson, 2010). Additionally, in some

• Harman and Stewardson mentioned that only a

  2018-11-07

  

  Harman and Stewardson (2005) mentioned that only a few published studies explicitly described the link between environmental flow targets and dam operating rules. To resolve the river management-driven issues and bridge the gap between a simple minimum stream flow target and the great complexity of

• However Foucault claims that political economy in fact was t

  2018-11-07

  

  However, Foucault claims that political economy in fact was the first economic school of thought to represent the beginning of a new governmentality by dividing power, knowledge, government and science properly. Foucault (2004, pp. 350–351) says that, unlike the resorts used by 17th century raison d

• Studies indicate that sleep difficulties increase significan

  2018-11-07

  

  Studies indicate that sleep difficulties increase significantly during the menopausal transition [2–6]. However, data on sleep quality in postmenopausal women are limited [2]. Despite the high prevalence of insomnia and its significant consequences, insomnia is often not properly evaluated and treat

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