• br Introduction The Middle East respiratory syndrome coronav

  2018-11-09

  

  Introduction The Middle East respiratory syndrome coronavirus (MERS-CoV) is the only lineage C betacoronavirus known to infect humans (Annan et al., 2013; Anthony et al., 2013; van Boheemen et al., 2012). Similarly to severe acute respiratory syndrome coronavirus (SARS-CoV), MERS-CoV infection ca

• AZD1152 Sigma receptors are arguably the most

  2018-11-09

  

  Sigma receptors are arguably the most mysterious signaling proteins. While the S1R was mischaracterized as an opioid receptor (Martin et al., 1976) until its gene sequence became available (Hanner et al., 1996), the S2R has evaded many attempts to decipher its genetic coding. For example, mass spect

• Neurotrophic factors regulate RGC survival and

  2018-11-09

  

  Neurotrophic factors regulate RGC survival and neurite growth through both common and distinct downstream signaling pathways (Goldberg et al., 2002). For example, MAPK/ERK and PI3K/AKT signaling pathways are involved in BDNF induced neuronal survival and axonal growth (Nakazawa et al., 2002) whereas

• mi2 Considerable work has gone into evaluating the impact of

  2018-11-09

  

  Considerable work has gone into evaluating the impact of putative adjuvants on innate immune activation and on adaptive immune responses to model mi2 and potential vaccines (Longhi et al., 2009; Kastenmuller et al., 2012; Trumpfheller et al., 2008; Stahl-Hennig et al., 2009; Perret et al., 2013; Ca

• br Experimental Procedures br Acknowledgments This

  2018-11-08

  

  Experimental Procedures Acknowledgments This work was supported by funding from auda ICR. F.B.A. was supported by the Erasmus Work Placement Programme. We thank Drs. Taiping Chen (MD Anderson Cancer Center) for providing J1 WT and Dnmt1-null ESCs and Masaki Okano (Riken) for providing TKO ESCs

• kainic acid Our previous study Ara et al demonstrated the pr

  2018-11-08

  

  Our previous study (Ara et al., 2011) demonstrated the protective efficacy of hypoxic-preconditioning against hypoxic–ischemic injury in newborn piglet model. We showed that hypoxic exposure for 3h, 24h before hypoxia–ischemia, was effective in reducing kainic acid damage in newborn piglets while i

• We recently found that E

  2018-11-08

  

  We recently found that E-cad function cannot be replaced by N-cad during the formation of the trophectoderm, the first polarized epithelium formed during mammalian development. In the blastocyst, the E-cad extracellular domain provides a unique and indispensable survival signal by facilitating Igf1r

• Our observations are consistent with previous findings

  2018-11-08

  

  Our observations are consistent with previous findings in vivo that Ahr expression is silenced at the 2-cell stage, becoming again detectable in late blastocysts (Peters and Wiley, 1995; Dey and Nebert, 1998; Wu et al., 2002) and in most developing organs during post-implantation development (Abbott

• The following are the supplementary data related to

  2018-11-08

  

  The following are the supplementary data related to this article. Acknowledgments This work was supported by Marie-Curie IEF FellowshipPIEF-GA-2009-254644 (J.F.) and the Netherlands Institute for Regenerative Medicine (NIRM) (E.W., M. vd. B. and T.N.). Introduction Human ES (hES) cells are p

• br Materials and methods br

  2018-11-08

  

  Materials and methods Results Discussion Here we establish a molecular signature for unmodified SCDSs that were initiated by individual multipotent SSCs in comparison with SCDSs that were initiated by Zalcitabine that were not multipotent, based upon their differentiation capacity as deter

• Cell adhesion molecules CAMs are transmembrane proteins that

  2018-11-08

  

  Cell adhesion molecules (CAMs) are transmembrane proteins that are responsible for mediating adhesion of cells to other cells and/or the extracellular matrix via their extracellular domains, while their intracellular domain interacts with the cytoskeleton. Thus, CAMs provide a direct link between th

• br Methods br Results br Discussion

  2018-11-08

  

  Methods Results Discussion The structural and functional immaturity of the differentiated cardiomyocytes are major obstacles for developing hPSC-VCM-based cell replacement therapies (Kong et al., 2010; van den Heuvel et al., 2014). Although a number of studies showed that the overall matura

• K03861 Our findings showing an increase of growth factors ex

  2018-11-08

  

  Our findings showing an increase of growth factors expression in miR133-CPCs upon stress conditioning and the amelioration of cardiac functions after miR133-CPCs transplantation post-AMI are in agreement with a recent publication that demonstrates that previous supplementation (“priming”) of SCA1+/C

• br Heteroplasmy mitochondrial segregation and disease In

  2018-11-08

  

  Heteroplasmy, mitochondrial segregation and disease In an individual with a mitochondrial disease, different cells or populations may have differing amounts of the mutant mitochondria, ranging from complete homoplasmy – individuals with all mutant mitochondrial DNA as occurs in Leigh\'s Syndrome

• An important step towards further ACC CSC characterization i

  2018-11-08

  

  An important step towards further ACC-CSC characterization is identification of CD markers which, in combination with CD133, may be used for FACS sorting and multiplexed CyTOF analysis of ACC-heterogeneity and their signaling states. Such studies may significantly advance understanding of ACC-CSC ro

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