• br Introduction Myotonic dystrophy dystrophia myotonica DM

  2020-03-25

  

  Introduction Myotonic dystrophy (dystrophia myotonica, DM) is an autosomal dominant disorder and the most common form of inherited muscular dystrophy in adults [1]. DM is characterised by a wide range of symptoms, including myotonia, progressive muscle loss, cataracts, cardiac conduction defects,

• br Acknowledgment br Introduction Pesticides are largely

  2020-03-25

  

  Acknowledgment Introduction Pesticides are largely used in agriculture to enhance food production and, to a lesser extent, to control unwanted pests and disease vectors in public health. However, these compounds are often associated with toxicity in non-target species including humans. Occupat

• The presence of a vicious cycle established between

  2020-03-25

  

  The presence of a “vicious cycle” established between tumor proliferation and paratumor osteolysis plays a crucial role in the development of primary bone tumors [53]. Cancer cells produce soluble factors that activate directly or indirectly via osteoblasts, osteoclast differentiation and maturation

• Because sex steroids and growth hormone play an important ro

  2020-03-25

  

  Because sex steroids and growth hormone play an important role in the development and maintenance of hepatic CYP450 enzyme expression and ER expression, it is possible that exposure to endocrine active agents during gestation and perinatally could alter expression of these proteins. Therefore, these

• The small intestine in addition to its

  2020-03-25

  

  The small intestine, in addition to its primary role of absorption, has the ability to metabolize drugs and other xenobiotics through phase 1 and phase 11 metabolisms [25] since almost all the cytochrome P450 Pefloxacin present in the liver are also present in the small intestine although, in lower

• Programmed cell death via apoptosis is associated

  2020-03-24

  

  Programmed cell death via apoptosis is associated with a series of morphological and biochemical characteristics, including cell shrinkage, the rapid increase of intracellular calcium, nuclear condensation, DNA fragmentation and the formation of apoptotic bodies. Known as a shared feature of most ap

• In summary the reduction of one or

  2020-03-24

  

  In summary, the reduction of one or more pro-inflammatory cytokines, such as TNF-α, IL-1β, IL-6, IL-8 was observed in almost all the monoterpenes studied. Increased levels of the anti-inflammatory cytokine IL-10 was shown to play a prominent function in the anti-inflammatory effect of monoterpenes,

• Pyrazolopyrimidines are bioisostere of purine exhibit promis

  2020-03-24

  

  Pyrazolopyrimidines are bioisostere of purine exhibit promising antitumor activity by competitively binding to the ATP active site of different kinase NKY 80 [16,17]. Several compounds of this family were found to induce apoptosis and/or reduce cell proliferation in various solid tumour and leukaemi

• We have previously reported the

  2020-03-24

  

  We have previously reported the characterization of A-127722, a novel, non-peptide endothelin antagonist that displays very high affinity binding (K=69 pM) with a more than 1000-fold greater affinity for human endothelin ETA than ETB receptor. Although A-127722 is >1000-fold more selective for endot

• Acknowledgments The authors thank Dr Vladimir Poltoratsky an

  2020-03-24

  

  Acknowledgments The authors thank Dr. Vladimir Poltoratsky and Zhihui Xiao for their help with the in vitro FRET assay. Support for this research was provided by Saint John’s University. Introduction We predicted the existence of endothelium-derived contractile factors (EDCFs) in 1982 [1]. In 1

• Based on our studies presented above atipamezole

  2020-03-23

  

  Based on our studies presented above, atipamezole can be used as a new in vitro and in vivo tool bio bio as a pan-CYP inhibitor for CYP mediated metabolism study. It carries many unique characteristics compared to ABT which is currently being widely used for this purpose. These new characteristics

• Midazolam oral clearance is used for characterization of bot

  2020-03-23

  

  Midazolam oral clearance is used for characterization of both intestinal and hepatic CYP3A activity. However, the identification and subsequent use of metabolic markers of CYP3A activity can eliminate the need for unnecessary administration of probe drugs such as midazolam. Such metabolic markers wo

• Behaviors were compared between saline and amphetamine pre t

  2020-03-23

  

  Behaviors were compared between saline and amphetamine pre-treatment groups at 24h and 2 weeks following the last treatment, or between pre-treatment groups that received vehicle or ASV-30 infusions, using separate two-way ANOVAs. Significant effects were analyzed further using Student–Newman–Keuls

• Two key enzymes play important roles

  2020-03-23

  

  Two key enzymes play important roles in the bioconversion of xylitol from d-arabitol, namely d-arabitol dehydrogenase (ArDH) and NADH-dependent xylitol dehydrogenase (XDH), respectively (Qi et al., 2014). In an earlier study, we developed a high xylitol yield strain by expressing xdh in E. coli BL21

• Alvocidib flavopiridol is a piperidine chromenone http

  2020-03-23

  

  Alvocidib (flavopiridol) is a piperidine-chromenone derivative (Fig. 6D) that is not FDA approved, but is in clinical trials for breast, endometrial, and several other cancers and hematological malignancies (Table 4) [[100], [101], [102], [103], [104]]. This drug targets CDK9 (IC50 = 3.2 nM) and CDK

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